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Moreover, improvements in mood observed in some patients during GLP1 therapy could relate to secondary benefits, such as weight loss, reduced glycemic variability, or enhanced selfefficacy, rather than a direct neurochemical effect

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Because it engages all three, retatrutide is often described as a triple agonist. For comparison, tirzepatide is a dual agonist (GLP-1 and GIP) and semaglutide is a single agonist (GLP-1)

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Advanced timing optimization Once you have the basics dialed in, there are additional timing considerations that can further refine your protocol