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Reports indicate that the incidence correlates with higher dosing, and onset occurs within the first month of therapy and upon dose escalation

Chem Biol Interact (2006) 160:140

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When it clings to metals, such as copper or iron, the beta-amyloid peptides misfold and clump together, causing inflammation and oxidation

The American Diabetes Association's Standards of Care emphasizes that patience during this titration period is essential for both efficacy and tolerability