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Across 809 participants with a mean starting weight of 114.2 kg, CagriSema produced 23.0 per cent weight loss when all patients adhered to treatment, against 25.5 per cent for tirzepatide

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4,5 Clinical outcomes Across phase II data for the once-daily, non-peptide GLP-1R agonist orforglipron in obese adults without diabetes, mean weight loss of 9.414.7% 6 was reported by week 36, depending on the dose, as compared to 2.3% with placebo

(A) Estimation of -cell glucose sensitivity by calculating the slope of the insulin secretion rate versus the blood glucose level

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Internist (Berl) 21(7):371-5, 1980