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Adding the glucagon receptor, which is what retatrutide does, introduces an entirely new metabolic lever that the body has not adapted to

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The association was still present when patients on medications for opioid, alcohol, or nicotine use disorder were excluded, with a 44% lower risk during active GLP-1 use and a 28% lower risk after discontinuation

Oral versions may help, but adoption lags despite benefits for heart, metabolism, and liver

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