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70+% of MVD-affected dogs with mild enlargement will never need any medications Studies have found that as many as 70% or more of MVD-affected dogs with a murmur and mild heart enlargement, will not progress to heart failure, even it they remain unmedicated

The interim analysis did not raise any concern over the safety of pimobendan administration." (Emphasis added.) the primary endpoint of the study, which was a composite of the development of left-sided congestive heart failure, or death presumed to be cardiac in origin Unfortunately, there is a lot wrong with that dreadfully vague statement

89 OECD (2018a)

For Research Use Only

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