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IFN- is responsible for macrophage activation, enhanced antigen presentation, and induction of nitric oxide-mediated killing mechanisms ( Our preclinical studies confirmed the previous findings that the T2DM group has lower levels of IFN- ( Figure 3E ) and TNF- ( Figure 3F ) when compared to healthy individuals

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In spite of the perceived hypotheses regarding the benefits of antioxidant supplementation on pregnancy outcomes, clinical trials investigating the use of antioxidants to treat reproductive disorders have reported largely conflicting results

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