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Cell 145 , 607621 (2011)

When oxidative stress causes excessive generation of oxygen free radicals, keap1 protein releases Nrf2 through the release of zinc ions, followed by the entrance of Nrf2 into the nucleus to bind to the ARE anti-oxidative stress element sequence, and activates gene transcription downstream of the ARE region, which then initiates the oxidative stress response and reduces the oxidative stress

It is studied in adults with overweight or obesity (BMI 27 or higher in REDEFINE 1) and in adults with type 2 diabetes (REDEFINE 2 and REIMAGINE 2)

We thank Dr Raymond Thomas (postdoctoral fellow) for published data on brain lipids and Drs Stephan Kahler and Anirudh Saronwala for their insight into propionic metabolism

Serum samples were obtained to measure CGRP concentration

Advances in experimental medicine and biology , 264 , 7984