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GLP-1R is expressed on neurons and glial cells across various brain regions [106]

Modulate cytokine production, reducing pro-inflammatory signaling

Patients should take steps to be as hydrated as possible, especially when suffering gastric side effects like vomiting or diarrhea

Oral GLP-1s (Lillys paltusotine-orforglipron, etc.) are expected in late 2025/2026, and might be covered differently (some plans treat orals less restrictively than injectables)

Semaglutide has also demonstrated cardiovascular benefits in people with overweight or obesity and established cardiovascular disease

Safety and tolerability of high doses of taspoglutide, a once-weekly human GLP-1 analogue, in diabetic patients treated with metformin: A randomized double-blind placebo-controlled study