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Furthermore, combination therapies that target multiple metabolic pathways, including glutamine metabolism, may enhance treatment outcomes and overcome resistance

In metabolic disease contexts, studies have found that supraphysiological doses of coenzyme Q 10 (CoQ 10 ) can specifically upregulate SQOR expression and simultaneously inhibit key enzymes (CBS and CSE) in the transsulfuration pathway, thereby reshaping the serinefolate cycle and nucleotide metabolism (Gonzlez-Garca et al., 2020)

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