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Deficiencies in ADSL are also believed to lead to decreased purine levels within the CNS, although the exact physiologic consequences of this are somewhat unclear

Popoviciu MS et al

In total, 36 studies were included in the qualitative analysis and 24 in the meta-analyses

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Benchmarking against SUSTAIN-6 and SURPASS-CVOT In the emulation of SUSTAIN-6 comparing semaglutide to sitagliptin, a proxy for placebo, in patients at moderate and high cardiovascular risk (Table 2 and Supplementary Table 19), the hazard ratio (HR) for the primary endpoint was 0.68 (95% confidence interval (CI) 0.600.77) compared to the trial estimate of HR 0.74 (95% CI 0.58 to 0.95)

Despite a small sample size of 48, these findings need further validation