Aldose Reductase Inhibitors Aldose reductase inhibitors (ARI) work by blocking the enzyme aldose reductase in the polyol pathway, which under hyperglycemic conditions converts excess glucose into sorbitol, a sugar alcohol that accumulates in nerves and causes osmotic stress, oxidative damage and impaired nerve function [116]
10.1016/j.psychres.2015.10.032 Psychiatry Res
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Journal of Preventive Medicine and Public Health, 45 (6), 344352