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GHK-Cu has a lower effective concentration range than the other components, typically requiring higher mass to achieve equivalent receptor engagement in tissue models

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Acknowledgements The researchers extend their appreciation to Postgraduate Studies & Research Sector, Assiut University for funding this work as a research number: AUN2025F

Peer review Peer review information Nature Reviews Rheumatology thanks Maria Sole Chimenti, Rubn Queiro and Eric Toussirot for their contribution to the peer review of this work