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1 Introduction Bone defects are commonly encountered in clinical practice and can arise from various causes, including trauma (e.g., fractures), age-related bone loss (e.g., osteoporosis), infections (e.g., osteomyelitis and periodontitis), cancer (e.g., surgical resection), genetic diseases (e.g., inherited bone marrow failure syndrome), and congenital defects (e.g., cleft palate)

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doi: 10.1186/s12906-021-03297-z

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Fraction of C

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Burney et al., 1990

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1 Gclc is expressed in non-epithelial cells, and its loss in tumors does cause redox or metabolic alterations

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