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MOTS-c half-life is approximately 2 to 4 hours, but the downstream cellular effects (mitochondrial biogenesis, gene expression changes) persist well beyond serum clearance

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Even something as simple as taking acetaminophen (e.g., Tylenol) can cause glutathione levels to plummet

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Recently it has become apparent that immune dysregulation rather than an overactive immune response per se can play a significant role in disease pathology

doi:10.1002/mco2.70241