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Symptoms of Pigmentary Maculopathy Blind spots Blurry vision or trouble reading Difficulty seeing in darkness or low light Distorted vision Retinal tissue damage Trouble adjusting between bright light and darkness The likelihood of developing pigmentary maculopathy increases based on the cumulative amount of Elmiron a patient takes over time

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Although the NMR structure does not show domain-domain interactions in ApoE4, fluorescence resonance energy transfer (FRET) and electron paramagnetic resonance (EPR) analyses have indicated that such interactions are stronger in ApoE4 compared to ApoE3

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