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Rushing escalation when symptoms are still present risks a step backward

10.1016/s0021-9258(18)99105-2 606 ThompsonJ

Selecting the most competent sperm for assisted reproductive technologies

Start with 500 mg once daily and titrate up

This results from G3P accumulation upstream and shunting of hexose monophosphates to the oxidative phase of the PPP to generate nicotinamide adenine dinucleotide phosphate (NADPH), which in turn fuels antioxidant systems