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The in vivo arm of the study involved treatment of the HFD mice, including AMPK1/2 knockout mice, with 50-mg/kg/day metformin in the drinking water and then assaying hepatocytes in vitro with the results indicating that complex 1 activity, mitochondria density and mitochondrial DNA were all increased via an AMPK-dependent mechanism (138)

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These include 3 : Damaging proteins and cell membranes , interfering with normal cellular function

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Egan, D., Kim, J., Shaw, R

Overall, this treatment is an excellent option for those seeking anti-aging benefits, glowing skin, and nourishment through the infusion of vitamins and minerals