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We observe that receptor subunits A and D swing laterally by ~19.521 at the ATD level and ~9.712 at the LBD-S1 to accommodate this asymmetric arrangement of LBD in UBP310 bound state

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Besides being a potential source of more reactive free radicals via Fenton reaction, physiological generation of H 2 O 2 fulfills a second messenger role and can be transported across membranes by aquaporins, a family of proteins that act as peroxiporins (Sies, 2014)

105,122 This produces H 2 O 2 and subsequently hydroxyl radicals via metal catalysis

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