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About 43% excreted unchanged in urine

The Social preference and recognition tests assess social behavior and memory [87]

Munne-Bosch, S., Mueller, M., Schwarz, K

The study will last for about 17-32 weeks Participants will have at least 5 in-house visits (where participants will stay at the clinic) and 17 out A Trial Investigating the Pharmacokinetic and Pharmacodynamic Properties of Insulin Icodec in Subjects With Type 2 Diabetes Intervention 1 Not provided Anticipated Start Date Not provided Actual Start Date 2020-10-16 Anticipated Date of Last Follow-up 2023-09-14 Estimated Primary Completion Date Not provided Estimated Completion Date Not provided Actual Primary Completion Date 2022-04-22 Actual Completion Date 2022-04-22 Age Cohort Genders Accepts pregnant individuals Unspecified Accepts lactating individuals Unspecified Accepts healthy individuals No Inclusion Criteria: * Male or female * Aged 18-75 years (both inclusive) at the time of signing informed consent * Body mass index between 18.0 and 38.0 kg/m\^2 (both inclusive) * HbA1c (glycated haemoglobin) below or equal to 9 percentage (75 mmol/mol) at screening * Current daily basal insulin treatment greater than or equal to 0.2 (I)U/kg/day with or without any of the following anti-diabetic drugs/regimens with stable doses greater than or equal to 90 days prior to the day of screening: 1) Any metformin formulation 2) Other oral antidiabetic drugs: DPP-4 nhibitors / SGLT2 inhibitors / Oral combination products (for the allowed individual oral antidiabetic drugs) * Oral or injectable GLP-1 Receptor Agonists Exclusion Criteria: * Known or suspected hypersensitivity to trial product(s) Not provided Interventional (clinical trial) 46 Not provided Single group assignment Not provided Open label Not provided Treatment NCT05790681 Phase I Completed Novo Nordisk A/S Insulin icodec is a new medicine which is under development for use in humans and is not yet available at the pharmacy

Oral pigmentation induced by smoking (smokers melanosis) may be associated with the effects of components of tobacco on oral melanocytes [29]

General methodological considerations for the assessment of nutritional influences on human cognitive functions