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Cellular susceptibility to ferroptosis is therefore governed by pathways controlling lipid metabolism, iron homeostasis, and redox balance

doi:10.1007/s11356-016-6823-x Ethics declarations Conflict of interest The authors declare that they have no conflict of interests

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10f-THF: 10-formyltetrahydrofolate 5mTHF: 5-methyltetrahydrofolate AICAR: P-ribosyl-5-amino-4-imidazole carboxamide CH = THF: 5-10-methenyltetrahydrofolate CH2-THF: 5-10-methylenetetrahydrofolate Cys: cysteine Cysta cystathionine DHF: dihydrofolate DMG: dimethylglycine dTMP: deoxythymidine monophosphate dUMP: deoxyuridine monophophate GAR: glycinamide ribonucleotide Glut: glutamate Glut: Cys glutamyl-cysteine Gly: glycine

Later REDEFINE trial programme obesity data summarised in 2025 reported up to 22.7% reduction at 68 weeks, though full peer-reviewed publication remains limited [6]

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