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doi: 10.1080/14656566.2016.1204294

A phased approach produces better long-term adherence

No dual or single agonist compound gives researchers access to the GCGR pathway

Microfocused ultrasound with visualization (MFU-V) targets multiple skin layers and the SMAS with ultrasound energy

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Its 2022 disclosure by Coskun and colleagues (Cell Metabolism) marked a deliberate extension of the dual-incretin agonist concept pioneered by tirzepatide, adding glucagon receptor engagement to the pharmacological palette