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Materials should address: Mechanism of action for each compound Evidence base (strong for monotherapy, absent for combinations) Realistic expectations for effects and side effects Importance of medical supervision Alternative evidence-based options Special Populations and Contraindications Who Should Avoid These Peptides

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Gallbladder complications Acute cholelithiasis (gallstones) was reported in at least one participant receiving 4.5 mg weekly cagrilintide in the phase 2 trial

Camilleri M (2021): Chronic intestinal pseudo-obstruction

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