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Beneficial acute effects of l-carnitine supplementation were observed after oral administration as little as one hour before exercise, and clinical practice guidelines have reported that l-carnitine supplementation is likely safe for up to 12 months

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In the SUSTAIN-6 trial of semaglutide for type 2 diabetes, EWDR occurred with significant glucose reductions, particularly in participants who were also receiving insulin or who had more than background retinopathy at baseline (Marso et al, 2016)

+ No, 1000 mg is well within the 2000 mg/day upper limit for adults

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