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The lack of central carbon and nitrogen catabolism not only leads to energy deficiency but also reduces the supply of the main metabolite anabolic precursors such as pyruvate, acetyl-CoA, glucose-6-phosphate, and erythrose 4-phosphate used for biomass biosynthesis 21
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The ideal would therefore be to provide large amounts of glycine (5 to 10 g per day) and moderate amounts of acetylcysteine (200 to 400 mg per day)
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