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22 Among the participants who reported any GI AEs, the vast majority experienced their first event during the doseescalation period, suggesting that the elevated prevalence of GI AEs with semaglutide versus placebo after dose escalation is primarily because of additional events being reported by participants who have previously experienced a GI AE

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Similarly, although retrospective cohort studies and case series have demonstrated benefit of infliximab and montelukast as rescue therapies for paradoxical reactions or IRIS 19,23,24 , our findings show that infliximab did not reduce mortality nor improve neurological outcomes, while montelukast was the poorest-performing HDT and in some measures worsened neuroinflammatory outcomes

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