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As with any supplement or medication, individual responses vary
If the skin feels tight against bone (common directly over the kneecap), move 2-3 cm laterally until you can pinch a fold
If back pain interferes with sleep, experiment with different sleeping positions and supportive pillows to find what works for your specific condition
Might be best to start a new thread if you do update as posts on older threads may get missed
Parenteral supplementation is by any path other than by mouth