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Such impairments closely parallel the mitochondrial respiratory deficits and elevated oxidative markers reported in cortical and limbic regions of depressed individuals, which would impair energy-dependent neuroplastic processes, intracellular signal transduction cascades, and activity-dependent protein synthesis required for synaptic maintenance, dendritic remodelling, and adaptive circuit function [138, 143]

By integrating these insights, we aim to demonstrate how targeting the MGBA provides novel multi-targeted opportunities to understand and combat neurodegenerative diseases

Colzato, L

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Both approaches produce comparable IGF-1 elevation

Observational data shows lower levels of reduced glutathione in darker skin compared to lighter skin [1][60]