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Postgraduate Medicine [Internet]

The absolute risk difference at week 156 was 1.1% (95% CI, 1.9% to 0.4%) in favour of semaglutide, which was identified as a clinically meaningful difference for this population

GLP-1s vs Traditional Weight Loss Medications Older options like phentermine, orlistat, or naltrexone-bupropion typically produce 5-10% weight loss compared to 15-22% with GLP-1 medications

Obesity is a multifactorial disease, and the inability to limit food intake, especially of high-calorie, palatable foods, is one of the contributing factors

This pharmacovigilance system is crucial for identifying previously unrecognised adverse effects, monitoring the safety profile of newly licensed medications like Mounjaro, and detecting rare but serious reactions that may not have been apparent during clinical trials