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Richard, University of Gothenburg, Sweden Updates Copyright 2025 Aristizbal-Colorado, Corredor-Rengifo, Sierra-Castillo, Lpez-Corredor, Vernaza-Trujillo, Weir-Restrepo, Izquierdo-Condoy, Ortiz-Prado, Rico-Fontalvo, Gmez-Mesa, Abreu-Lomba and Rivera-Martnez

In the SUSTAIN 8 study, patients with T2DM exhibited a lean mass decrease of 2.3 kg alongside a total weight loss of 5.3 kg, resulting in 43.4% of weight loss attributable to lean mass, while the ratio of lean mass to total mass increased by 1.2% from the baseline [111]

There is no confirmed evidence that retatrutide causes thyroid cancer in humans

No injections, no controlled substance restrictions, no hormonal manipulation

For women with insulin resistance related to PCOS or metabolic syndrome, GLP-1s can help alongside weight loss

Body composition beyond the scale Weight does not distinguish between fat loss and muscle loss