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GLP-1 receptor agonist medications include drugs FDA-approved for type 2 diabetes (since exenatide in 2005) and for chronic weight management (liraglutide / Saxenda in 2014), and they are available as a subcutaneous injection (most products) or as an oral tablet (Rybelsus only, as of April 2026)

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In the STEP clinical trials, overweight adults without diabetes lost an average of around 1415% of their body weight after 68 weeks of treatment

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Users also frequently ask how quickly they should expect to feel or notice a difference

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