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Furthermore, purified flavonoids and phenolics, such as kaempferol-3-O-glucuronide, puerarin, and esculetin, have been shown to alleviate metabolic disorders and activate protective pathways like Nrf2/Keap1 and PI3K/AKT, highlighting the models strength in delineating multi-target mechanisms (Ahmad et al., 2019

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Current evidence indicates that SESN1 is uniquely activated by oxidative stress in a p53-dependent manner: p53, a major tumor suppressor and stress-induced transcription factor, mediates this activation [15]

Respiratory mucosal immunity against SARS-CoV-2 after mRNA vaccination

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