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ACI is primarily indicated for younger, active patients with isolated, symptomatic full-thickness defects larger than 22.5 cm 2 , and is generally not recommended in advanced OA with diffuse degeneration (Minas et al., 2010
Treatment with metformin promoted cell survival and ameliorated memory impairments (Sritawan et al., 2020)
Am J Med Sci 2010
The mechanisms are fundamentally different, and that difference has significant clinical implications
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, Sommerfeld, K
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