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The relationship between body weight and optimal dosing has not been established through controlled trials

Often, people will notice the effects of B12 injections within 24 to 72 hours after their first dose

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While most people can safely have injections, there are a few exceptions

After getting a B12 shot, you should watch out for these symptoms and see a doctor if you have: Strong pain where you got the shot Some stomach upset Feeling swollen Skin feeling itchy for a while In really rare cases, there might be more serious risks like: A severe allergic reaction called anaphylaxis Fluid build-up in the lungs Heart problems Blood clots in the bodys blood vessels A type of blood cancer, called polycythemia vera

Everything below is compound-level evidence, presented so you can see what is and is not established