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Metformin, sulfonylureas, and generic pioglitazone remain first-line agents on TennCare formularies

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GLP-1 medications are considered when appetite regulation has been a consistent barrier, even with healthy efforts

Moreover, in mouse brain mitochondria another study showed that OGC and DIC are both expressed in cortical neurons and astrocytes (Wilkins et al., 2013)

Oral formulations are forecast to expand at a 6.39% CAGR between 2026 and 2031 as products like orforglipron near approval