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It is important to note that claims about increased energy expenditure in humans remain insufficiently evidenced at this stage, and the net glycaemic effects reflect observed trial outcomes rather than a straightforward mechanistic reduction in hepatic glucose output the concurrent glucagon receptor agonism may, in fact, influence hepatic glucose production in a complex and not fully characterised manner

Frias JP, Bastyr EJ 3rd, Vignati L et al (2017) The Sustained Effects of a Dual GIP/GLP-1 Receptor Agonist, NNC0090-2746, in Patients with Type 2 Diabetes

There was no bacon sizzle here with applause

Obviously, this functionality will be extremely powerful if it can also be attuned to block the dopamine spikes tied to substance abuse

Expect retatrutide to list at or slightly above tirzepatide, not below it