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There are no controlled trials of clebopride (D2 antagonist) in gastroparesis other than in dyspepsia with radiologically delayed gastric emptying, a criterion not currently accepted for gastroparesis ( 1 and 5-HT 4 agonist and 5-HT 2 antagonist) was superior to placebo in a parallel design study of 19 patients with dyspepsia associated with postprandial distress and mildly to moderately delayed gastric emptying (Portincasa et al., 2009)

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Horowitz M, Flint A, Jones KL, Hindsberger C, Rasmussen MF, Kapitza C, Doran S, Jax T, Zdravkovic M, Chapman IM

For those who plateau at 1.0 mg or need greater appetite suppression, 1.7 mg provides a meaningful step up