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Thus, in tumors, citrate (originating from reductive carboxylation of glutamine or, if applicable, OXPHOS, or acetate) does not diminish phosphofructokinase-1, the step with the highest flux-control coefficient in glycolysis
[Abstract] Sci Rep
SIRT3 lysine deacetylase inhibitors specifically target SIRT3 without affecting its structurally similar counterparts, SIRT1 and SIRT2 185,186
whereas IGF-1 gene therapy suppressed these effects to improve hepatic steatosis and fibrogenesis
Dhillon S
This latter family is generally involved in the metabolism of eicosanoids and glutathione (GSH), thus being referred to as MAPEG (membrane-associated proteins in eicosanoid and glutathione metabolism) [22]
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