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GLP-1 receptor agonist medications are under investigation and active litigation for alleged links to serious gastrointestinal and vision-related injuries, including gastroparesis, bowel obstruction, gallbladder disease, cyclic vomiting syndrome, ileus, and non-arteritic anterior ischemic optic neuropathy (NAION)

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Randomized trials (direct AD studies) Liraglutide (ELAD Phase 2b): In people with mild AD, 12 months of liraglutide slowed brain atrophy (MRI) and was associated with an ~18% slower cognitive decline versus placeboencouraging but still preliminary and not yet a practice-changing Phase 3 outcome