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One group has reported that exenatide inhibits proliferation and induces apoptosis of the mouse CT26 colon cancer cell line and increases their susceptibility to topoisomerase inhibitor irinotecan

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33.4 pM for GIP) but approximately 13-fold weaker potency than GLP-1 in activating GLP-1R (EC50 = 934 pM for tirzepatide vs.70.5 pM for GLP-1)

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Step 4: Introduce the Water to the Peptide (The Delicate Part) This is the most critical physical step in the entire process