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Between 35-80% of people with PCOS are insulin resistant, meaning this hormone doesnt function as intended

In certain embodiments, any controlled release otic formulation described herein increases the exposure of a therapeutic agent and increases the length of time that the concentration of a therapeutic agent is above C min by about 30%, about 40%, about 50%, about 60%, about 70%, about 80% or about 90% compared to a formulation or composition that is not a controlled release otic formulation or composition

Int J Mol Sci 24(4):3207 Wang Y, Wu L, Fu J, Lv H, Guan X, Xu L, Chen P, Gao C, Hou P, Ji M (2013) Hyperthyroid monkeys: a nonhuman primate model of experimental Graves disease

Rhee JJ, Han J, Montez-Rath ME, Chertow GM

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