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doi: 10.1097/MNH.0b013e328350313e
Gao Y, Kong F, Song X, Shang J, Yao L, Xia J, Peng Y, Liu W, Gong H, Mu M, Cui H, Han T, Chen W, Wu X, Yang Y, Yan X, Jin Z, Wang P, Zhu Q, Chen L, Zhao C, Zhang D, Jin W, Wang D, Wen X, Liu C, Jia J, Mao Q, Ding Y, Jin X, Zhang Z, Mao Q, Li G, Niu J
Cu 2+ is released in the acidic TME while simultaneously increasing the electronproton dipoledipole interaction-related time C, shortening the T1 of the PDA NPs to enhance the longitudinal relaxivity (r1), thus serving as a T1-weighted contrast agent in MRI
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This occurs because the skin and supporting structures (Cooper's ligaments) may not retract fully after the underlying fat tissue diminishes, particularly if weight loss is rapid