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VacA generates a protective intracellular reservoir for Helicobacter pylori that is eliminated by activation of the lysosomal calcium channel TRPML1

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Specifically, while light chains of IgG2, IgG3, and IgG4 pair to the CH1 domain of their corresponding HCs through a disulfide bridge between cysteine-214 of the light chain and cysteine-127 at the N-terminus of the CH1, the corresponding pairing in IgG1 occurs with cysteine-233 at the C-terminus of CH1 [258]

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When a GHRH pathway agonist (CJC-1295) and a GHS-R pathway agonist (Ipamorelin/GHRP-2) are introduced together, the total cellular response can be significantly higher than the sum of their individual effects

Craft WH, Underwood LE