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Advantage : CagriSema Side Effect Profile# CagriSema : GI adverse events in 79.6% of CagriSema group vs 39.9% placebo in REDEFINE 1

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Subsequent reviews have reinforced this finding, suggesting GLP-1s may dampen reward signaling in the brains dopamine pathways, which are involved in addiction and compulsive behaviors (Kalra et al., 2024

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