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Upregulation of AQP4 Improves Blood-Brain Barrier Integrity and Perihematomal Edema Following Intracerebral Hemorrhage

Alongside liraglutide, semaglutide has been shown to effectively improve motor impairments, rescue tyrosine hydroxylase (TH) levels, reduce -synuclein accumulation, chronic inflammation response in the brain and lipid peroxidation, inhibit mitochondrial mitophagy signaling and protect dopaminergic neurons in the substantia nigra and striatum in MPTP mouse models of PD [81]

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Moreover, although Ang-1 and Ang-2 are not known drugs for protecting the glycocalyx, intervening in Ang-1 and Ang-2 may serve as targets for inhibiting glycocalyx degradation

doi:10.17226/6015

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