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Sobos Insight: We design a glide path, not a cliff
Recently, the pharmacotherapy of MASLD mainly focuses on three parts of mechanisms: anti-inflammatory (ASK1 inhibitors), anti-diabetic (GCGR agonists, PPAR agonists), and prevention of lipotoxicity (FXR agonists, FGF21 analogues) (Wei et al., 2024)
The results revealed that the drastic inhibition of GLP-1 secretion, caused by the shutdown of the main pathway via the SSTRs-Gi axis, is the main cause of pasireotide-induced hyperglycemia
For non-diabetic patients whose insurance denies coverage entirely, the cash-pay options are the same as for everyone else: NovoCare ($149 to $349/month), LillyDirect ($299 to $449/month), or patient assistance programs if income-eligible
The cost of GLP-1 drugs is a hot topic: the federal government announced last week that it has reached a deal with pharmaceutical companies to lower the cost of GLP-1 drugs, but it remains unclear exactly how this will affect patients
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