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5c) with the 30 mg/kg treatment delivering a 13% decrease in body weight compared to a 1.4% reduction for the control group at day 26

Puylaert, P

Use Berberine for Supportive Effects Berberine is getting a lot of media attention for its potential ability to promote GLP-1 activity and more in ways that may be useful in supporting those on GLP-1 agonists .[21-23] Berberine is an alkaloid compound found in many plants, most notably goldenseal (Hydrastis canadensis), barberry (Berberis vulgaris), and goldthread (Coptis chinensis)

you need to know how much of the active compound is truly getting to where it needs to go

doi: 10.2337/dc09-1203 55 Elkind-HirschKMarrioneauxOBhushanMVernorDBhushanR