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In Davila's experience, the best outcomes happen when stopping is treated as a planned transition rather than an abrupt finish, with sustainable habits around eating, movement and stress already in place

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Finally, patients should understand that if urgent or emergent colonoscopy is required, the procedure may need to proceed regardless of medication status, with the anesthesia team taking appropriate precautions based on individual risk assessment

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Future work should be focused and lean: enroll truly deficient, higher-risk patients, standardize formulations and dosing, and test event-driven hard endpoints aligned to mechanism, while embedding translational markers to confirm on-target biology