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It makes B12 a less likely explanation, though a borderline number alongside ongoing symptoms is still worth a second look

What exists is literature discussing why researchers have theorized these pairings might be of interest, not evidence that they produce any specific outcome together

When skin bacteria detect abundant external B12, they reduce their own production of the vitamin

Journal of Medicinal Chemistry , 61(15), 64156425

What is missing There is no published human pharmacokinetic study of subcutaneous AOD-9604, no published human topical or intranasal exposure data, no Phase 3 efficacy trial, no long-term safety data beyond 24 weeks, and no published human cartilage or joint outcome data