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Quick Answer: Insomnia is not listed as a common side effect of tirzepatide in FDA prescribing information or major clinical trials, though some patients report sleep disturbances that may be indirectly related to gastrointestinal symptoms or metabolic changes

In addition, these therapies reduce glucagon secretion and delay gastric emptying, facilitating weight reduction through a neuronally mediated satiety effect [1, 2]

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Wheeler et al

11 The well-known mechanism for p70S6K1 to promote survival is that p70S6K1 phosphorylates mouse double minute 2 (MDM2) leading to polyubiquitination and degradation of p53, and thus represses p53-dependent apoptosis

Decreased efficacy was observed when this dose was spread over two administrations (50 mg/kg i.p