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Photoaffinity labeling of this GST with tritiated 5-azido-indole-3-acetic acid suggested that the phytohormone indole-3-acetic acid (IAA) serves as a regulator or substrate of the enzyme (Hahn and Strittmatter, 1994)

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Cuprizone-induced demyelination in animals is accepted for studying multiple sclerosis-related lesions and is characterized by degeneration of oligodendrocytes more than by a direct attack on the myelin sheet (12)

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The clinical titration starts at 0.25 mg weekly and increases every four weeks up to a maintenance dose of 2.4 mg weekly, though some research protocols extend up to 4.5 mg